EVALUATION OF TOPICAL ADMINISTRATIONS OF ML7 IN A RAT MODEL OF SCOPOLAMINE-INDUCED DRY EYE. SIGNED REPORT.

Contract Research Organization: Ophthalmology Research - Iris Pharma

Iris Pharma, a Contract Research Organization, provides preclinical and clinical research in ophthalmology: ocular safety, efficacy, ocular pharmacokinetics, clinical trials, bioanalytical testing

http://www.iris-pharma.com

Neuroptis

neuroptis, bitoech, ophtalmology, ophtalmologie, oeil sec, dry eye, research, ml7,

http://www.neuroptis.com

EVALUATION OF TOPICAL ADMINISTRATIONS OF ML7

IN A RAT MODEL OF SCOPOLAMINE-INDUCED DRY EYE.

CONCLUSION AND SIGNATURES

Conclusion:

Oral administration of Cyclosporine A improved tear production and reversed the corneal

staining by 3 weeks of treatment and validated the assay.

Topical administration of ML7 was effective to reverse the corneal staining induced by

the scopolamine on Day 7.

2. STATEMENT ML7. MANAGEMENT AND STUDY DIRECTION

I, the undersigned, declare that this study was performed according to the study plan and I

assume the responsibility of the validity of reported data.

Study Director; LaurencG FERAILLE, Ph.D

General Manager; Pierre-Paul ELENA, Ph.D