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Neuroptis Dry Eye Project with ML 7 (Myosin Light Chain Inhibitor)
10 mai 2015

Dry eye symptoms correlated with non-ocular conditions

 Dry eye symptoms correlated with non-ocular conditions

 

 

 

 

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Strategies for Managing Dry Eye

Richard L. Lindstrom, MD: Dry eye syndrome affects approximately 15% of the U.S. population, and the prevalence in Asia may be as high as 20% to 30%.1 Numerous underlying risk factors and diseases are associated with dry eye, and most people experience symptoms of dry eye at some point in their lives.

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Participants completed questionnaires regarding PTSD, depression, non-ocular pain and dry eye symptoms. Tear film parameters were also measured.

Results showed that correlations between the dry eye questionnaire scores and depression, PTSD and non-ocular pain were moderate in strength as well as significant. Conversely, correlations between the dry eye questionnaire scores and tear film measurements were weak in strength and largely insignificant.

"The finding that non-ocular measures correlate more closely to dry eye symptoms than tear parameters has a number of different possible explanations, three of which are summarized here," the authors concluded. "First, patients with non-ocular conditions may be suffering from central sensitization, a process that affects generalized pain perception and pain related behaviors. Second, patients with underlying psychiatric conditions, including anxiety, may be misinterpreting ocular surface sensations. Third, patients with non-ocular pain and psychiatric conditions may be taking medications that affect their tear film status. Regardless of the underlying cause, our findings suggest that non-ocular factors are more strongly associated with dry eye symptoms than are tear film parameters.

"These findings have implications for treatment of dry eye," they continued. "Current dry eye treatment paradigms focus on treating ocular surface pathology in order to improve dry eye symptoms. Our findings suggest that systemic findings may need to be considered, and perhaps addressed, when developing a personalized dry eye treatment algorithm." – by Chelsea Frajerman

Disclosure: The researchers report no relevant financial disclosures.

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