ml7 - Neuroptis Dry Eye Project with ML 7 (Myosin Light Chain Inhibitor)

12 juin 2016

Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury.

Pulm Circ. 2016 Jun;6(2):234-9. doi: 10.1086/686491. Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury. Wang T1, Mathew B2, Wu X3, Shimizu Y3, Rizzo AN4, Dudek SM4, Weichselbaum RR5, Jacobson JR4, Hecker L6, Garcia JG3....

Posté par Eric Belot à 17:14 - Commentaires […] - Permalien [#]

Tags: ML7, MLCK inhibitor, 2016, bronchoalveolar lavage

Partager cet article

Vous aimez ?

0 vote

30 novembre 2015

Role of myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability

Diab Vasc Dis Res. 2015 Nov 24. pii: 1479164115610469. [Epub ahead of print] Role of myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability in vitro and in vivo. Wu F 1, Guo X 2, Xu J 2,...

Posté par Eric Belot à 21:12 - Commentaires […] - Permalien [#]

Tags: publications, ML7, 2015, MLCK, MLCK inhibitor, Glycation, endothelial, hyperpermeability

Partager cet article

Vous aimez ?

0 vote

2 novembre 2015

NEW PUBLICATIONS UPTO OCT. 31ST 2015

NEW PUBLICATIONS UPTO OCT. 31ST 2015 1. Cornea. 2015 Oct 27. [Epub ahead of print] Efficacy and Safety of Carbomer-Based Lipid-Containing Artificial Tear Formulations in Patients With Dry Eye Syndrome. Chung SH 1, Lim SA , Tchach H . Author information:...

Posté par Eric Belot à 20:53 - Commentaires […] - Permalien [#]

Tags: publications, Tarsal glands Meibomius glands protection, ML7, Tarsal glands Meibomius glands dysfunction, Dry eye, diagnosis, DED, New Therapies, MLCK inhibitor, News

Partager cet article

Vous aimez ?

0 vote

2 novembre 2015

Matrix Metalloproteinase 9-induced inc. in intestinal epith. tight junct. permeability contributes to severity of DSS colitis

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 29:ajpgi.00256.2015. doi: 10.1152/ajpgi.00256.2015. [Epub ahead of print] Matrix Metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of...

Posté par Eric Belot à 20:32 - Commentaires […] - Permalien [#]

Tags: ML7, MLCK, MLCK inhibitor, Science

Partager cet article

Vous aimez ?

0 vote

9 septembre 2015

NEUROPTIS BIOTECH TO SELL ML7 FOR R&D ACTIVITIES

NEUROPTIS IS THE OWNER OF PATENTS ON THE SYNTHESIS OF PURIFIED AND STABLE ML7 ACCORDING TO THE REQUIREMENTS OF EMEA AND FDA WITHOUT ANY DEGRADATION PRODUCT NEUROPTIS HAS ALSO DEVELOPED METHODS OF DOSAGE OF ML7 (HPLC) IN DIFFERENT BIOLOGICAL LIQUIDS NEUROPTIS...

Posté par Eric Belot à 15:24 - Commentaires […] - Permalien [#]

Tags: patents, ML7, formulation, Synthesis, MLCK inhibitor, Price

Partager cet article

Vous aimez ?

0 vote

7 septembre 2015

Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating MLCK Expression through Cross-talk with p38 MAPK

Asian Pac J Cancer Prev. 2015;16(14):5835-42. Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating Myosin Light Chain Kinase Expression through Cross-talk with p38 MAPK. Papers in the journal Asian Pacific Journal of Cancer Prevention:...

Posté par Eric Belot à 21:55 - Commentaires […] - Permalien [#]

Tags: ML7, MLCK inhibitor, Colon Cancer, Melatonin, Migration of cells

Partager cet article

Vous aimez ?

0 vote

28 août 2015

Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

Biophys J. 2015 Aug 18;109(4):670-86. doi: 10.1016/j.bpj.2015.07.006. Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading. Li Y 1, Lovett D 1, Zhang Q 1, Neelam S 2, Kuchibhotla RA 1, Zhu R 3, Gundersen GG 3, Lele TP 4, Dickinson RB 5....

Posté par Eric Belot à 12:01 - Commentaires […] - Permalien [#]

Tags: publications, ML7, Research, MLCK inhibitor, News

Partager cet article

Vous aimez ?

0 vote

15 août 2015

The Rho-GTPase effector ROCK regulates meiotic maturation of the bovine oocyte via MLC phosphorylation

The Rho-GTPase effector ROCK regulates meiotic maturation of the bovine oocyte via myosin light chain phosphorylation and cofilin phosphorylation. Gene Information - OKdb General Comment upstream of Hippo signaling NCBI Summary: This gene encodes a protein...

Posté par Eric Belot à 13:59 - Commentaires […] - Permalien [#]

Tags: ML7, Research, MLCK inhibitor, Bovine oocyte, Rocck

Partager cet article

Vous aimez ?

0 vote

11 août 2015

Biphasic force response to iso-velocity stretch in airway smooth muscle.

Biphasic force response to iso-velocity stretch in airway smooth muscle. Biphasic force response to iso-velocity stretch in airway smooth muscle Airway smooth muscle (ASM) in vivo is constantly subjected to oscillatory strain due to tidal breathing and...

Posté par Eric Belot à 04:02 - Commentaires […] - Permalien [#]

Tags: ML7, 2015, MLCK inhibitor, Science, Biphasic Force, Smooth Muscle, iso-velocity

Partager cet article

Vous aimez ?

0 vote

27 juillet 2015

Interaction in endothelium of nmMLCK and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity.

Interaction in endothelium of non-muscular myosin light-chain kinase and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity. 0319 : Non muscular myosin light chain kinase (nmMLCK) and NF-κB pathway interaction in endothelium...

Posté par Eric Belot à 13:44 - Commentaires […] - Permalien [#]

Tags: ML7, 2015, Inflammation, MLCK, MLCK inhibitor, Fundamental Study, Science

Partager cet article

Vous aimez ?

0 vote

15 juillet 2015

UNEXPECTED PROTECTIVE EFFECT OF ML7 -MLCK INHIBITOR- ON TARSAL GLANDS

Ocular inflammation and corneal alteration by benzalkonium chlorids in rabbits: an unexpected protective effect of ML7 - a myosin light chain kinase inhibitor - on tarsal glands LIEN: Ocular_inflammation_and_corneal_alteration_by_benzalkonium_chlorids_in_rabbits_STUDY_BOSTON_MONTREAL_...

Posté par Eric Belot à 17:59 - Commentaires […] - Permalien [#]

Tags: Tarsal glands Meibomius glands protection, ML7, Tarsal glands Meibomius glands dysfunction, Trial Meibomian gland Tarsal gland, treatment, Precinical, MLCK inhibitor, Rabbits

Partager cet article

Vous aimez ?

0 vote

29 juin 2015

MLCK inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis

Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis Vascular endothelial dysfunction (VED) is an important factor in the initiation and development of atherosclerosis...

Posté par Eric Belot à 22:06 - Commentaires […] - Permalien [#]

Tags: ML7, MLCK inhibitor, Atherosclerosis, vascular endothelial dysfunction

Partager cet article

Vous aimez ?

0 vote

22 juin 2015

Myosin light chain kinase involved in change of intestinal mucosal barrier function in nonalcoholic steatohepatitis mice model.

Myosin light chain kinase involved in change of intestinal mucosal barrier function in nonalcoholic steatohepatitis mice model. Lien: P0588 [Article in Chinese] Zhang Y , Li J , Chi Y , Li M , Pan X , Zhang Q , He X , Liu Y 1. Author information Abstract...

Posté par Eric Belot à 14:20 - Commentaires […] - Permalien [#]

Tags: publications, ML7, 2015, MLCK, MLCK inhibitor, Gastro-enterology

Partager cet article

Vous aimez ?

0 vote

8 juin 2015

Rho kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

Rho kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure. Escuin S 1, Vernay B 1, Savery D 1, Gurniak CB 2, Witke W 2, Greene ND 1, Copp AJ 3. Author information Abstract The cytoskeleton is widely...

Posté par Eric Belot à 18:22 - Commentaires […] - Permalien [#]

Tags: ML7, Rho Kinase Inhibitor, 2015, MLCK, MLCK inhibitor, Mouse, Neurulation, spinal neural tube

Partager cet article

Vous aimez ?

0 vote

18 mai 2015

A novel collagen gel-based measurement technique for quantitation of cell contraction force with ML7

A novel collagen gel-based measurement technique for quantitation of cell contraction force with ML7 J R Soc Interface. 2015 May 6;12(106). doi: 10.1098/rsif.2014.1365. A novel collagen gel-based measurement technique for quantitation of cell contraction...

Posté par Eric Belot à 11:43 - Commentaires […] - Permalien [#]

Tags: ML7, Cytoskeletal contractibility, Research, Mechanism, MLCK, Cell, Inhibition

Partager cet article

Vous aimez ?

1 vote

6 mai 2015

ML7 MOLECULE ANIMATION

VUE EN 3D DE LA MOLECULE ML7 animation 3D ML7 720p

Posté par Eric Belot à 15:13 - Commentaires […] - Permalien [#]

Tags: ML7, MLCK, 3D, Animation

Partager cet article

Vous aimez ?

1 vote

4 mai 2015

Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia

Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion. Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following...

Posté par Eric Belot à 18:57 - Commentaires […] - Permalien [#]

Tags: ML7, 2015, MLCK, Links, Lung, Neurology, Reperfusion, ischemia

Partager cet article

Vous aimez ?

0 vote

3 mai 2015

CEREP STUDY ON ML7 WITH BIOPRINT

CEREP Cerep provides all services to support drug discovery and hit-to-lead development, from combinatorial chemistry, high throughput screening (HTS) and profiling (HTP), medicinal and computational chemistry, molecular, cellular and animal pharmacology,...

Posté par Eric Belot à 16:19 - Commentaires […] - Permalien [#]

Tags: ML7, pharmacology, Safety, Bioprint, Cerep, Profile, Study

Partager cet article

Vous aimez ?

1 vote

2 mai 2015

SYNTHESIS ML7 BY PROVENCE TECHNOLOGIES

Flow Chart: OPH4_11 "WE DO RECOMMAND PROVENCE TECH. FOR THEIR PROFESSIONALISM AND THEIR CLIENT RELATIONS" (Dr. Eric Belot) Provetech - Fine Chemistry http://www.provetech.com

Posté par Eric Belot à 20:15 - Commentaires […] - Permalien [#]

Tags: patents, ML7, Synthesis, Defects, Provence Technologies, Purity

Partager cet article

Vous aimez ?

0 vote

27 avril 2015

Dry Eye Publications up to Apr. 27th 2015

1. Optom Vis Sci. 2015 Apr 23. Corneal Confocal Microscopy in Dry Eye Treated with Corticosteroids. Villani E 1, Garoli E, Termine V, Pichi F, Ratiglia R, Nucci P. Author information: 1*MD Department of Clinical Sciences and Community Health, University...

Posté par Eric Belot à 16:09 - Commentaires […] - Permalien [#]

Tags: publications, ML7, Dry eye, diagnosis, treatment, DED

Partager cet article

Vous aimez ?

0 vote