Articles populaires – Neuroptis Dry Eye Project with ML 7 (Myosin Light Chain Inhibitor)

9 septembre 2015

NEUROPTIS BIOTECH TO SELL ML7 FOR R&D ACTIVITIES

NEUROPTIS IS THE OWNER OF PATENTS ON THE SYNTHESIS OF PURIFIED AND STABLE ML7 ACCORDING TO THE REQUIREMENTS OF EMEA AND FDA WITHOUT ANY DEGRADATION PRODUCT NEUROPTIS HAS ALSO DEVELOPED METHODS OF DOSAGE OF ML7 (HPLC) IN DIFFERENT BIOLOGICAL LIQUIDS NEUROPTIS...

Posté par Eric Belot à 15:24 - Commentaires […] - Permalien [#]

Tags: patents, ML7, formulation, Synthesis, MLCK inhibitor, Price

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24 septembre 2015

NEW PUBLICATIONS UPTO SEPTEMBER 18TH 2015

NEW PUBLICATIONS UPTO SEPTEMBER 18TH 2015 The effects of long-term topical glaucoma medication on conjunctival i Long-term use of topical drugs can induce changes in theconjunctiva and ocular surface. To determine theconjunctival changes resulting from...

Posté par Eric Belot à 22:26 - Commentaires […] - Permalien [#]

Tags: publications, Dry eye, DED, New Therapies, News, artificial tears, cyclosporin, pain

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23 novembre 2015

NEW PUBLICATIONS UPTO NOV. 21ST 2015

NEW PUBLICATIONS UPTO NOV. 21ST 2015 The Cataract Patient is a Dry Eye Patient By Josh Johnston, OD, FAAO 11/15/2015 A 63-year-old female presented in the clinic for an eye exam for the first time in five years with a best-corrected visual acuity of 20/40...

Posté par Eric Belot à 15:54 - Commentaires […] - Permalien [#]

Tags: publications, Dry eye, DED, 2015, Cataract, News

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3 juillet 2015

What Makes LipiFlow® and LipiView® II So Successful in Our Practice

What Makes LipiFlow® and LipiView® II So Successful in Our Practice Meibomian Gland Dysfunction | Treatment | TearScience TearScience® is the only company dedicated to identifying, diagnosing, and treating MGD, the leading cause of dry eye, with an FDA-cleared...

Posté par Eric Belot à 15:54 - Commentaires […] - Permalien [#]

Tags: Tearscience website, Tarsal glands Meibomius glands dysfunction, Dry eye, diagnosis, DED, 2015, Devices, LipiFlow

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8 juin 2015

Rho kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure.

Rho kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure. Escuin S 1, Vernay B 1, Savery D 1, Gurniak CB 2, Witke W 2, Greene ND 1, Copp AJ 3. Author information Abstract The cytoskeleton is widely...

Posté par Eric Belot à 18:22 - Commentaires […] - Permalien [#]

Tags: ML7, Rho Kinase Inhibitor, 2015, MLCK, MLCK inhibitor, Mouse, Neurulation, spinal neural tube

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11 août 2015

NEW PUBLICATIONS UPTO AUG. 8TH 2015

NEW PUBLICATIONS UPTO AUG. 8TH 2015 Brief Report: Ultrasonographic Assessment of Salivary Gland Response to Rituximab in Primary Sjögren's Syndrome Jousse-Joulin, S., Devauchelle-Pensec, V., Cornec, D., Marhadour, T., Bressollette, L., Gestin, S., Pers,...

Posté par Eric Belot à 20:33 - Commentaires […] - Permalien [#]

Tags: publications, 2015, News, Sjögren's syndrome, AIDS, Gougerot Sjögren's Syndrom, Thymosin, Salivary Gland

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26 mai 2015

News through publications up to May 25th 2015

JBP485 promotes tear and mucin secretion in ocular surface epithelia Journal name: Scientific Reports Volume: 5, Article number: 10248 DOI: doi:10.1038/srep10248 Dry eye syndrome (DES) is one of the most frequently encountered ocular diseases. Epidemiological...

Posté par Eric Belot à 20:31 - Commentaires […] - Permalien [#]

Tags: publications, Dry eye, Tearfilm quality, DED, 2015, New Therapies, Mucin

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20 juillet 2015

NEW PUBLICATIONS UPTO JULY 18TH 2015

NEW PUBLICATIONS UPTO JULY 18TH 2015 A Pragmatic Approach to the Management of Dry Eye Disease:... : Optometry & Vision Science Dry eye disease (DED) is a highly prevalent chronic ocular disorder that can lead to significant discomfort and visual disturbance....

Posté par Eric Belot à 14:24 - Commentaires […] - Permalien [#]

Tags: publications, Meibomian, Tarsal glands Meibomius glands dysfunction, Dry eye, diagnosis, DED, 2015, New Therapies

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13 juillet 2015

NEW PUBLICATIONS UPTO JULY THE 11TH, 2015 ON DED

NEW PUBLICATIONS UPTO JULY THE 11TH, 2015 ON DED Ocular Adverse Effects of Systemic Treatment With Isotretinoin Objective To examine whether isotretinoin therapy could result in deleterious ocular effects, as previously described in case report studies....

Posté par Eric Belot à 21:41 - Commentaires […] - Permalien [#]

Tags: publications, Dry eye, diagnosis, treatment, DED, 2015, Sjögren's syndrome, Steroids

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4 mai 2015

Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia

Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion. Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following...

Posté par Eric Belot à 18:57 - Commentaires […] - Permalien [#]

Tags: ML7, 2015, MLCK, Links, Lung, Neurology, Reperfusion, ischemia

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3 mai 2015

CEREP STUDY ON ML7 WITH BIOPRINT

CEREP Cerep provides all services to support drug discovery and hit-to-lead development, from combinatorial chemistry, high throughput screening (HTS) and profiling (HTP), medicinal and computational chemistry, molecular, cellular and animal pharmacology,...

Posté par Eric Belot à 16:19 - Commentaires […] - Permalien [#]

Tags: ML7, pharmacology, Safety, Bioprint, Cerep, Profile, Study

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24 mars 2015

Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease (HALR)

Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease (HALR) This study is currently recruiting participants. (see Contacts and Locations ) Verified December 2014 by University of California, Los Angeles Sponsor: University...

Posté par Eric Belot à 16:48 - Commentaires […] - Permalien [#]

Tags: Dry eye, Case Control study, 2014, Cosmetic, Hyalunoric Acid, Lid retraction, Recruiting, Thyroid Eye Disease

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17 avril 2015

Amakem Therapeutics

AMAKEM THERAPEUTICS Amakem is a clinical stage ophthalmology company developing innovative new treatments for serious eye conditions. The Company’s lead program is based on AMA0076, a novel, locally-acting Rho kinase (ROCK) inhibitor, in clinical development...

Posté par Eric Belot à 20:24 - Commentaires […] - Permalien [#]

Tags: Biotech Finances, Dry eye, Rho Kinase Inhibitor, DED, Glaucoma, Amakem Therapeutics, Belgium, Venture

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13 avril 2015

Publications up to April 13 th 2015

PubMed Results Items 1 - 13 of 13 1. Cutan Ocul Toxicol. 2015 Apr 8:1-5. [Epub ahead of print] The ocular surface side effects of an anti-psychotic drug, clozapine. Ceylan E 1, Ozer MD, Yilmaz YC, Kartal B, Yildiz Ekinci D, Çinici E, Aksu Ceylan N. Author...

Posté par Eric Belot à 21:32 - Commentaires […] - Permalien [#]

Tags: publications, pictures, glands, Dry eye, diagnosis, DED, 2015, Scintigraphy

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9 décembre 2015

NEW PUBLICATIONS ABOUT DRY EYE SYNDROM UPTO DEC. 4TH 2015

NEW PUBLICATIONS ABOUT DRY EYE SYNDROM UPTO DEC. 4TH 2015 SciStream This free news service SciBite.com, we hope you find it useful. SciBITES scans 100s of biomedically relevant websites every second of every day, hunting for the targets, indications,...

Posté par Eric Belot à 15:32 - Commentaires […] - Permalien [#]

Tags: publications, Dry eye, DED, 2015, Drug development, News

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27 juillet 2015

Interaction in endothelium of nmMLCK and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity.

Interaction in endothelium of non-muscular myosin light-chain kinase and the NF-κB pathway is critical to lipopolysaccharide-induced vascular hyporeactivity. 0319 : Non muscular myosin light chain kinase (nmMLCK) and NF-κB pathway interaction in endothelium...

Posté par Eric Belot à 13:44 - Commentaires […] - Permalien [#]

Tags: ML7, 2015, Inflammation, MLCK, MLCK inhibitor, Fundamental Study, Science

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18 mai 2015

A novel collagen gel-based measurement technique for quantitation of cell contraction force with ML7

A novel collagen gel-based measurement technique for quantitation of cell contraction force with ML7 J R Soc Interface. 2015 May 6;12(106). doi: 10.1098/rsif.2014.1365. A novel collagen gel-based measurement technique for quantitation of cell contraction...

Posté par Eric Belot à 11:43 - Commentaires […] - Permalien [#]

Tags: ML7, Cytoskeletal contractibility, Research, Mechanism, MLCK, Cell, Inhibition

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29 mai 2015

May 27, 2015 Keratoconjunctivitis sicca (Dry Eye) - Pipeline Review, H1 2015

May 27, 2015 Keratoconjunctivitis sicca (Dry Eye) - Pipeline Review, H1 2015 Press release distribution, EDGAR filing, XBRL, regulatory filings | Business Wire The global leader in press release distribution and regulatory disclosure. Public relations...

Posté par Eric Belot à 13:15 - Commentaires […] - Permalien [#]

Tags: Dry eye, DED, 2015, Keratoconjunctivitis Sicca, Research, Competitors, Pipe Line

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19 octobre 2015

NEW PUBLICATIONS UPTO OCT. 19TH 2015

NEW PUBLICATIONS UPTO OCT. 19TH 2015 IOVS | Therapeutic Effects of Epidermal Growth Factor on Benzalkonium Chloride-Induced Dry Eye in a Mouse Model http://iovs.arvojournals.org 1. J Ocul Pharmacol Ther. 2015 Oct 15. [Epub ahead of print] Preformulation...

Posté par Eric Belot à 16:26 - Commentaires […] - Permalien [#]

Tags: publications, Dry eye, DED, 2015, News

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15 avril 2015

Tear film osmolarity measurements using the TearLabTM ARVO 2014

245 Dry Eye Disease #1 Monday, May 05, 2014 11:00 AM–12:45 PM Exhibit/Poster Hall SA Poster Session Program #/Board # Range: 1967–2021/B0266–B0320 Organizing Section: Cornea Program Number: 1967 Poster Board Number: B0266 Presentation Time: 11:00 AM–12:45...

Posté par Eric Belot à 19:39 - Commentaires […] - Permalien [#]

Tags: Dry eye, diagnosis, DED, 2014, TEARLAB, ARVO, Veterinary

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27 avril 2015

MAPK3/1 (ERK1/2) and Myosin Light Chain Kinase in Mammalian Eggs Affect Myosin-II Function and Regulate the Metaphase II State i

Biol Reprod. 2015 Apr 22. pii: biolreprod.114.127027. MAPK3/1 (ERK1/2) and Myosin Light Chain Kinase in Mammalian Eggs Affect Myosin-II Function and Regulate the Metaphase II State in a Calcium- and Zinc-Dependent Manner. McGinnis LA, Lee HJ, Robinson...

Posté par Eric Belot à 15:56 - Commentaires […] - Permalien [#]

Tags: ML7, Calcium, Cell Cycle, Cytoskeleton, MLCK, Meiotic spindle, Oocyte

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6 octobre 2015

NEW PUBLICATIONS UPTO OCT 2ND 2015

NEW PUBLICATIONS UPTO OCT 2ND 2015 Dry Eye The online home of the AOP, Optometry Today and CET for the optometry profession and industry. http://www.optometry.co.uk 1. J Cataract Refract Surg. 2015 Aug;41(8):1699-704. doi: 10.1016/j.jcrs.2014.12.056....

Posté par Eric Belot à 21:32 - Commentaires […] - Permalien [#]

Tags: publications, Dry eye, diagnosis, DED, 2015, News, Sjögren's syndrome

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28 août 2015

Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

Biophys J. 2015 Aug 18;109(4):670-86. doi: 10.1016/j.bpj.2015.07.006. Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading. Li Y 1, Lovett D 1, Zhang Q 1, Neelam S 2, Kuchibhotla RA 1, Zhu R 3, Gundersen GG 3, Lele TP 4, Dickinson RB 5....

Posté par Eric Belot à 12:01 - Commentaires […] - Permalien [#]

Tags: publications, ML7, Research, MLCK inhibitor, News

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2 juin 2015

TARGETING OCULAR DISORDERS

Targeting Ocular Disorders - Overview Ophthalmological pharmacology has historically lacked systematic understanding of disease mechanisms, especially of those for the back of the eye. This is now changing with the discovery of novel targets and pathways...

Posté par Eric Belot à 19:56 - Commentaires […] - Permalien [#]

Tags: Dry eye, pharmacology, 2015, Boston, Research, Ocular Therapeutics, SYMPOSIUM

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21 mai 2015

Researchers develop nanoparticle eye drops to combat dry eye syndrome

Researchers develop nanoparticle eye drops to combat dry eye syndrome NANOTECHNOLOGY: A NEW APPROACH FOR OCULAR DRUG DELIVERY SYSTEM: 3714 Published on October 9, 2014 at 10:31 AM For the millions of sufferers of dry eye syndrome, their only recourse...

Posté par Eric Belot à 17:55 - Commentaires […] - Permalien [#]

Tags: Dry eye, treatment, Tearfilm quality, DED, 2014, Nanoparticules, Nanotechnologies

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