Dry eye findings worsen with anticholinergic therapy in patients with urge incontinence

The Role of Medications in Causing Dry Eye

1Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger BouLevard, Portland, OR 97239-4197, USA 2 The Milton J. Dance , Jr. Head & Neck Center, 6569 North Charles Street, Baltimore, MD 21204, USA Received 25 June 2012; Revised 14 August 2012; Accepted 21 August 2012 Academic Editor: Anthony J.

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1.	Int Urogynecol J. 2015 Dec 7. [Epub ahead of print] Dry eye findings worsen with anticholinergic therapy in patients with urge incontinence. Ozen Tunay Z1,2, Ozdemir O3, Ergintürk Acar D3, Cavkaytar S4, Ersoy E4. Author information:  1Ophthalmology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. zuhaltunay@gmail.com. 2Göz Hastalıkları Polikliniği, Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Talatpaşa Bulvarı, Altındağ, 06200, Ankara, Turkey. zuhaltunay@gmail.com. 3Ophthalmology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. 4Urogynecology Department, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Abstract INTRODUCTION AND HYPOTHESIS:  To evaluate the effects of oral anticholinergic (OAC) drugs on tear secretion in women with overactive bladder over a 3-month follow-up period. METHODS:  In this prospective study, 108 women with a diagnosis of overactive bladder were evaluated. All patients were examined ophthalmologically at baseline (day 0), and after 1 month (day 30) and 3 months (day 90) of OAC treatment. Tear film break-up time (BUT) and Schirmer 1 test results were recorded. The subjective complaints of the patients including dry mouth, and burning, dryness and foreign body sensation in the eyes, were also recorded. The chi-squared test or the paired sample t test as appropriate, was used for statistical analysis. RESULTS:  The mean age of the patients was 51.8 ± 9.2 years (30 - 69 years). The most frequent subjective complaints were dry mouth and dry eyes and both complaints were significant on both day 30 and day 90. Both tear film BUT and Schirmer 1 test results were significantly lower on day 30 and day 90. Dry eye measurement values worsened with prolongation of OAC treatment (p = 0.037 and p = 0.012 for BUT, and p = 0.046 and p = 0.035 for Schirmer 1 test, on day 30 and day 90, respectively). CONCLUSIONS:  OAC treatment in women with overactive bladder significantly and progressively affects tear secretion.
	PMID: 26642801 [PubMed - as supplied by publisher]